Motif ID: HOX{A5,B5}.p2

Z-value: 2.284


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
HOXA5 3202 homeobox A5
HOXB5 3215 homeobox B5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA5chr7_-_27149750-0.864.5e-05Click!
HOXB5chr17_-_44026321-0.421.2e-01Click!


Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_144124547 5.268 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr6_+_33495824 4.984 NM_006772
SYNGAP1
synaptic Ras GTPase activating protein 1
chr12_+_53241365 4.386 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr16_+_31446703 4.068 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr11_+_4621731 3.687 NM_152430
OR51E1
olfactory receptor, family 51, subfamily E, member 1
chr11_+_4859624 3.570 NM_001004759
OR51T1
olfactory receptor, family 51, subfamily T, member 1
chr1_+_26517032 3.458 CD52
CD52 molecule
chr1_+_202000906 3.453 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr19_-_47040347 3.437 NM_173506
LYPD4
LY6/PLAUR domain containing 4
chr1_+_26516967 3.307 NM_001803
CD52
CD52 molecule
chr19_+_55844446 3.298 NM_001195076
LOC342918
hypothetical protein LOC342918
chr6_+_34590624 3.245 PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr22_-_25343959 3.140 NM_001887
CRYBB1
crystallin, beta B1
chr1_+_26517045 3.055 CD52
CD52 molecule
chr19_-_54958326 3.038 NM_021733
TSKS
testis-specific serine kinase substrate
chr17_+_71109734 3.024 MYO15B
myosin XVB pseudogene
chr19_+_8023887 3.008 NM_005624
CCL25
chemokine (C-C motif) ligand 25
chr1_+_203503214 2.732 TMCC2
transmembrane and coiled-coil domain family 2
chr6_+_31662954 2.731 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr11_-_56905178 2.664 NM_006093
PRG3
proteoglycan 3
chr6_-_29563657 2.649 NM_052967
MAS1L
MAS1 oncogene-like
chr11_+_118259684 2.635 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr1_+_148020869 2.619 NM_000566
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr19_-_56537189 2.590 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr11_+_63030099 2.535 NM_001142535
NM_001142536
NM_033101
LGALS12


lectin, galactoside-binding, soluble, 12


chr22_-_21231421 2.433 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr8_+_21972804 2.385 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr1_+_160618143 2.349 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr1_+_111215343 2.331 NM_001040033
CD53
CD53 molecule
chr1_-_143706300 2.323 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr17_-_72151314 2.315 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chr1_-_143706196 2.310 PDE4DIP
phosphodiesterase 4D interacting protein
chr7_-_106088565 2.295 NM_175884
FLJ36031
hypothetical protein FLJ36031
chrX_+_128700605 2.279 NM_003399
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr8_+_21972631 2.249 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr14_+_20306425 2.216 NM_022360
EDDM3B
epididymal protein 3B
chr17_-_36276987 2.207 NM_000223
KRT12
keratin 12
chr22_+_21870293 2.196


chr3_-_197023096 2.188 MUC4
mucin 4, cell surface associated
chr16_-_56562512 2.176 NM_001135639
NM_001297
CNGB1

cyclic nucleotide gated channel beta 1

chr2_+_113648020 2.167 NM_012455
PSD4
pleckstrin and Sec7 domain containing 4
chr1_-_26517342 2.155 NM_145345
UBXN11
UBX domain protein 11
chr10_-_75080784 2.104 NM_024875
SYNPO2L
synaptopodin 2-like
chr1_-_143706265 2.073 PDE4DIP
phosphodiesterase 4D interacting protein
chr6_+_31976754 2.065 NM_001178063
C2
complement component 2
chr1_-_120737416 1.982 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chrX_+_48265107 1.952 NM_006579
EBP
emopamil binding protein (sterol isomerase)
chr1_-_120737466 1.952 NM_001004340
NM_001017986
FCGR1A
FCGR1B

Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)

chr11_-_56761250 1.952 NM_005161
APLNR
apelin receptor
chr1_+_12627152 1.931 NM_001013630
AADACL4
arylacetamide deacetylase-like 4
chr14_-_20128721 1.892 NM_001024822
RNASE12
ribonuclease, RNase A family, 12 (non-active)
chr20_-_55533544 1.830 NM_080618
CTCFL
CCCTC-binding factor (zinc finger protein)-like
chr14_+_59782222 1.798 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr19_-_53187151 1.792 NM_001128326
BSPH1
binder of sperm protein homolog 1
chr20_-_48741481 1.784


chr1_+_154855709 1.776 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr19_+_54621499 1.774 NM_001195256
LOC645971
hypothetical protein LOC645971
chr8_-_66863841 1.765 NM_002603
PDE7A
phosphodiesterase 7A
chr1_-_159459999 1.729 NM_001643
APOA2
apolipoprotein A-II
chr9_-_33385265 1.689 AQP7
aquaporin 7
chr6_+_44076281 1.660 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chrX_-_130251068 1.656 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr20_+_44083667 1.644 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr2_+_113648036 1.631 PSD4
pleckstrin and Sec7 domain containing 4
chr3_-_197023544 1.618 NM_004532
NM_018406
NM_138297
MUC4


mucin 4, cell surface associated


chr17_-_37590910 1.593 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr22_+_38090120 1.560 NM_145738
SYNGR1
synaptogyrin 1
chr19_+_45797413 1.559 LTBP4
latent transforming growth factor beta binding protein 4
chr1_+_116718011 1.558 NM_001160233
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr9_-_124370576 1.535 NM_001004454
OR1L8
olfactory receptor, family 1, subfamily L, member 8
chr7_+_156128431 1.519 NM_001184997
RNF32
ring finger protein 32
chr12_+_48784057 1.512 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr8_-_95298706 1.497 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr22_-_35938298 1.480 NM_001051
SSTR3
somatostatin receptor 3
chr17_+_35484204 1.457 THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr6_-_42270671 1.451 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr1_-_159459814 1.449 APOA2
apolipoprotein A-II
chr1_-_26070330 1.440 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr11_+_65049102 1.438 NM_001048218
NM_020680
SCYL1

SCY1-like 1 (S. cerevisiae)

chr6_-_31736488 1.435 NM_021184
C6orf47
chromosome 6 open reading frame 47
chr7_+_142670624 1.435 NM_001143679
NM_001143680
NM_001143681
NM_015917
GSTK1



glutathione S-transferase kappa 1



chr11_-_111287657 1.431 NM_001885
CRYAB
crystallin, alpha B
chr22_+_18388656 1.412 C22orf25
chromosome 22 open reading frame 25
chr17_+_53769659 1.408 LOC100506779
hypothetical LOC100506779
chr10_+_35524060 1.402 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr1_-_151867338 1.401 NM_005979
S100A13
S100 calcium binding protein A13
chr19_-_56549853 1.399 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr7_-_150352484 1.396 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr1_+_147006065 1.377 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr16_-_83209140 1.374 NM_021149
COTL1
coactosin-like 1 (Dictyostelium)
chr19_-_18220009 1.367 NM_000923
PDE4C
phosphodiesterase 4C, cAMP-specific
chr1_+_15655809 1.367 NM_033440
CELA2A
chymotrypsin-like elastase family, member 2A
chr1_+_24701363 1.349 RCAN3
RCAN family member 3
chrX_-_130250880 1.339 IGSF1
immunoglobulin superfamily, member 1
chr1_+_143326315 1.334 NM_001037675
NBPF10
NBPF9
NBPF8
neuroblastoma breakpoint family, member 10
neuroblastoma breakpoint family, member 9
neuroblastoma breakpoint family, member 8
chr1_+_20385164 1.327 NM_152376
UBXN10
UBX domain protein 10
chr19_-_40925151 1.324 NM_024660
TMEM149
transmembrane protein 149
chr19_+_40824486 1.314 NM_014209
ETV2
ets variant 2
chr20_-_43889339 1.303 NM_003279
TNNC2
troponin C type 2 (fast)
chr12_+_46802695 1.283 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr22_+_18388633 1.250 C22orf25
chromosome 22 open reading frame 25
chr16_-_83209185 1.250 COTL1
coactosin-like 1 (Dictyostelium)
chr7_-_141187689 1.244 NM_001008270
NM_001171951
PRSS37

protease, serine, 37

chr2_-_85490984 1.242 CAPG
capping protein (actin filament), gelsolin-like
chr1_+_153232685 1.204 NM_018655
LENEP
lens epithelial protein
chr11_+_5573906 1.189 NM_058166
TRIM6
tripartite motif containing 6
chrX_-_130250715 1.188 NM_001170963
IGSF1
immunoglobulin superfamily, member 1
chr11_-_117600918 1.157 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr3_+_39484073 1.152 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr5_-_34020445 1.150 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr16_-_19440786 1.142 NM_016641
GDE1
glycerophosphodiester phosphodiesterase 1
chr2_-_157892391 1.134 NM_001009959
ERMN
ermin, ERM-like protein
chr2_-_96927557 1.119 NM_016490
FAM178B
family with sequence similarity 178, member B
chr1_-_33613729 1.117 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr1_-_153444304 1.115 NM_007112
THBS3
thrombospondin 3
chr11_+_63030131 1.115 LGALS12
lectin, galactoside-binding, soluble, 12
chr1_-_146091224 1.110 NBPF24
neuroblastoma breakpoint family, member 24
chr9_-_129580732 1.102 NM_170600
SH2D3C
SH2 domain containing 3C
chr7_+_99263571 1.079 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr1_-_120240635 1.077 NM_021794
ADAM30
ADAM metallopeptidase domain 30
chr2_+_218992053 1.076 NM_007127
VIL1
villin 1
chr19_+_56956264 1.066 NM_001005738
FPR2
formyl peptide receptor 2
chr11_+_5574440 1.063 NM_001003818
NM_001198644
NM_001198645
NM_001003819
TRIM6


TRIM6-TRIM34
tripartite motif containing 6


TRIM6-TRIM34 readthrough
chr3_+_23961739 1.063 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr1_+_146843980 1.046 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr1_+_204484081 1.041 NM_001910
NM_148964
CTSE

cathepsin E

chr3_+_185300660 1.039 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr11_-_124831391 1.033 FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr7_-_107667728 1.032 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr3_-_42892636 1.026 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chrX_-_152863251 1.019 NM_002910
RENBP
renin binding protein
chr1_+_148511806 1.013 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr6_+_31662454 1.010 NM_205837
LST1
leukocyte specific transcript 1
chr1_-_12599934 1.004 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr6_+_31651319 1.003 NM_000594
TNF
tumor necrosis factor
chr2_+_42649348 0.998 MTA3
metastasis associated 1 family, member 3
chr1_-_120189301 0.996 NM_001047980
NBPF7
neuroblastoma breakpoint family, member 7
chr19_-_54636425 0.994 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr16_-_82633262 0.989 NM_001080442
SLC38A8
solute carrier family 38, member 8
chr6_-_76259976 0.989 NM_015687
FILIP1
filamin A interacting protein 1
chr22_-_34930705 0.981 NM_030643
NM_145660
APOL4

apolipoprotein L, 4

chr7_+_2248966 0.953 NM_198953
NM_198954
NUDT1

nudix (nucleoside diphosphate linked moiety X)-type motif 1

chr17_-_31290472 0.953 NM_020426
LYZL6
lysozyme-like 6
chr5_+_357290 0.938 NM_020731
AHRR
aryl-hydrocarbon receptor repressor
chr19_-_12853249 0.932 NM_001375
DNASE2
deoxyribonuclease II, lysosomal
chr12_+_6751930 0.932 NM_002286
LAG3
lymphocyte-activation gene 3
chr14_+_20568184 0.926 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr3_-_180460372 0.924 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr2_-_167058829 0.922 SCN7A
sodium channel, voltage-gated, type VII, alpha
chr1_+_144286544 0.919 PIAS3
protein inhibitor of activated STAT, 3
chr1_+_28458546 0.918 NM_031459
SESN2
sestrin 2
chr2_-_85490997 0.917 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr1_-_166149867 0.914 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr1_-_20318578 0.910 NM_012400
PLA2G2D
phospholipase A2, group IID
chr1_-_36338436 0.903 NM_005202
COL8A2
collagen, type VIII, alpha 2
chr2_+_108590032 0.887 NM_001193482
LIMS1
LIM and senescent cell antigen-like domains 1
chrX_-_107112244 0.885 NM_031273
TEX13B
testis expressed 13B
chr2_+_97696462 0.881 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr11_-_47330797 0.875 NM_000256
MYBPC3
myosin binding protein C, cardiac
chr2_-_74498351 0.875 NM_001145054
C2orf81
chromosome 2 open reading frame 81
chr17_-_70039187 0.867 NM_174892
CD300LB
CD300 molecule-like family member b
chr16_-_2776606 0.866 NM_152891
PRSS33
protease, serine, 33
chr6_+_42896771 0.861 NM_015349
KIAA0240
KIAA0240
chr19_-_8548232 0.857 MYO1F
myosin IF
chr1_-_28375722 0.851 NM_001164723
PTAFR
platelet-activating factor receptor
chr2_-_167058901 0.850 SCN7A
sodium channel, voltage-gated, type VII, alpha
chr1_+_233597350 0.835 NM_001079515
NM_003193
TBCE

tubulin folding cofactor E

chr19_+_62434188 0.829 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr22_+_19651446 0.829 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr1_+_55044323 0.829 NM_001110533
NM_152607
C1orf177

chromosome 1 open reading frame 177

chr3_+_131547048 0.828 NM_153264
COL6A5
collagen, type VI, alpha 5
chr7_-_99312591 0.826 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chr5_+_148766632 0.821 LOC728264
hypothetical LOC728264
chr14_+_95222506 0.813 NM_004918
NM_199206
TCL1B

T-cell leukemia/lymphoma 1B

chr17_+_53769562 0.812 LOC100506779
hypothetical LOC100506779
chr6_+_31661934 0.794 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr19_-_52614151 0.791 MEIS3
Meis homeobox 3
chr10_-_12125028 0.788 NM_080599
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr6_-_29503468 0.784 NM_013937
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr6_-_31977747 0.778 NM_181842
ZBTB12
zinc finger and BTB domain containing 12
chr2_+_220087135 0.776 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr3_+_46514488 0.770 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr17_-_39499527 0.763 LSM12
LSM12 homolog (S. cerevisiae)
chr6_+_108987703 0.763 NM_201559
FOXO3
forkhead box O3
chr1_-_36721010 0.760 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr17_-_8004671 0.760 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chrX_+_148433970 0.759 NM_001171909
CXorf40A
chromosome X open reading frame 40A
chr6_-_32259974 0.750 NM_001136
NM_172197
AGER

advanced glycosylation end product-specific receptor

chr1_+_160868822 0.741 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr19_+_39437292 0.740 NM_014686
KIAA0355
KIAA0355
chr19_-_56919032 0.739 NM_001523
HAS1
hyaluronan synthase 1
chr1_+_157441824 0.731 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr1_+_233597385 0.729 TBCE
tubulin folding cofactor E
chr9_+_134843918 0.728 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr1_+_246682699 0.727 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr12_+_63090008 0.727 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr2_+_42649105 0.723 NM_020744
MTA3
metastasis associated 1 family, member 3
chr8_-_22841173 0.714 NM_144962
PEBP4
phosphatidylethanolamine-binding protein 4
chr12_-_52015696 0.712 NM_152860
SP7
Sp7 transcription factor
chr13_-_38462857 0.708 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.41 1.39e-02 GO:0003823 antigen binding